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In the City of Vancouver, one of the key functions of the Development Control Board (DCB) is the monitoring of major sites. The DCBC hires a Major Sites Monitoring Officer (MSMO) to oversee the site’s infrastructure and ensure that developer contributions are paid. This includes plumbing, electrical, sanitary plumbing, lead paint abatement, load-bearing structural systems, and weatherization.
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EBOV GP binding site residues
The GP protein contains several epitopes, which may play a role in the escape of viral particles. One of these epitopes, located in the GP1 glycan cap, is known as CA45. Mutations in CA45 may increase the bar for viral escape.
Pep42 is known to bind to HSPA5. Pep42 is known to be associated with HSPA5, which is associated with EBOV and human papillomavirus E6. This association suggests that HSPA5 could be a drug target. Because the GP1 protein accumulates in the ER, a drug targeting the ER might be a viable option to stop EBOV infection.
The binding site of HSPA5 and EBOV GP1 proteins has several similar residues. Both proteins have hydrophobic and hydrophilic interactions. However, there are several differences between the two. The HSPA5 structure contains two salt bridges, while the EBOV GP1 structure contains six H-bonds and four hydrophobic contacts.
Developer contributions to major sites are increasing across Australia and in some cities, such as Sydney and Melbourne, they account for up to 12% of the total construction cost. However, these contributions are not publicly disclosed, a major challenge for policy evaluation. However, recent reforms in some states are beginning to change that.
Developer contributions are a potential alternative funding source to rates and provide a means for developers to contribute to the infrastructure costs that ensure new homes and neighborhoods are habitable and connected to existing transport hubs. In addition, they help to improve the quality of the urban realm, which may reduce traffic and congestion.
The Framework sets out various circumstances where Developer Contributions are required. It is important to note that the thresholds are not rigid; schemes that fall below thresholds may still need Developer Contributions. In addition, the impact of a proposed development will be considered, and each case will be assessed individually.